Antiviral medications for influenza. 2015, Korownyk, Can Fam Physician

Based on substandard and biased research, largely unpublished, antiviral drugs oseltamivir (Tamiflu) and zanamivir (Relenza) shorten the course of influenza by 0.6-0.7 days. They do not reduce the risk of pneumonia and hospitalization.
Sales of Tamiflu more than 18 billion dollars.Most of the sold stocks were not used.Preparations are not recommended if it has been more than 48 hours from the onset of symptoms.


Complications: tracking down the data on oseltamivir. 2009, Cohen, BMJ

An interesting investigation by BMJ about how Cochrane tried to access data from clinical studies of Tamiflu. In 2009, a Japanese pediatrician asked Cochrane why their systematic review was based on unpublished manufacturer data, rather than on their own analysis Cochrane had to respond to this within six months, and for a long time tried to get the original data from the manufacturer, they never got it.
This led to the fact that Cochrane decided to change its methodology for systematic reviews.


The Tamiflu fiasco and lessons learnt. 2015, Gupta, Indian J Pharmacol

Another interesting article about Tamiflu: As it turned out that despite the lack of scientific evidence of the effectiveness and safety of this drug, WHO, FDA, CDC and EMA (European FDA analogue) not only recommended it for treatment and prevention of influenza, but also recommended to store them in large quantities. More: [1], [2]. Here it is reported that the risk of death within 12 hours after taking Tamiflu 1.9 times higher than after taking Relenza, and the risk of deterioration 5.9 times higher.


Vitamin D for influenza. 2015, Schwalfenberg, Can Fam Physician

Tamiflu and Relenza are useless drugs that do more harm than good. I have seen how patients in nursing homes and staff begin because of them vomiting, diarrhea, hallucinations, delirium, and worsening cognitive function. The IOM recommends taking 600 IU vitamin D for those under 70 years old to reach the level of 50 nmol/L in 97.5% of people. However, their recommendation contains a statistical error, and in fact, you need to take 8800 IU to achieve this For several years, as I and my colleague have given vitamin D to patients, and most of them have a vitamin level of more than 100 nmol/L. We rarely see patients with influenza or ARD, and when we see, we give them shock doses of vitamin D (a one-time dose of 50,000 IU, or 10,000 IU three times a day for 2-3 days) Symptoms completely pass for 48-72 hours Vitamin D costs a penny for 1000 IU, that is, this treatment costs less dollar.

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