DTaP/Hib Vaccine

Haemophilus influenzae

Diminution of the anti-polyribosylribitol phosphate response to a combined diphtheria-tetanus-acellular pertussis/Haemophilus influenzae type b vaccine by concurrent inactivated poliovirus vaccination. 2000, Rennels, Pediatr Infect Dis J

When Hib vaccine is given together with the inactivated polio vaccine (IPV), significantly fewer Hib antibodies get produced than would be produced if it were given with a live polio vaccine. It was also found that children that are given Hib and DTaP vaccines at the same time develop significantly fewer tetanus antibodies.
Injection sites were different for the vaccines (one in the arm, and other in the leg). It was previously unknown that giving two vaccines at the same time causes immune interference between them. The biological mechanism of this phenomenon is unknown.

Haemophilus influenzae

Vaccine antigen interactions after a combination diphtheria-tetanus toxoid-acellular pertussis/purified capsular polysaccharide of Haemophilus influenzae type b-tetanus toxoid vaccine in two-, four- and six-month-old infants. 1997, Pichichero, Pediatr Infect Dis J

DTaP/Hib combined vaccine produces significantly fewer Hib and tetanus antibodies than would be produced if they were given separately. More: [1], [2], [3].
Nevertheless, in almost all countries, Hib is part of a penta- or hexavalent vaccine, together with IPV and tetanus (Pentacel, Infanrix, etc.)

Haemophilus influenzae

Non-pertussis components of combination vaccines: problems with potency testing. 1999, Sesardic, Biologicals

- DTaP/Hib combined vaccine (with acellular pertussis vaccine) produces 10 times less Hib antibodies than DTP/Hib combined vaccine.
- If the injection site for Hib and DTaP vaccines is the same then 5-15 times less Hib antibodies developed, as compared to choosing different injection sites for the two vaccines.
- DTaP produces significantly fewer diphtheria antibodies than DTP.

Haemophilus influenzae

Risk of vaccine failure after Haemophilus influenzae type b (Hib) combination vaccines with acellular pertussis. 2003, McVernon, Lancet

After England switched to the acellular pertussis vaccine (DTaP/Hib), an almost 7-times increase in Hib incidence was reported.

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