21% of pediatric specialists and 10% of total pediatricians will refuse at least one vaccination for their child.
19% of specialist pediatricians and 5% of general pediatricians will delay MMR vaccination until 1.5 years of age.
18% of specialist pediatricians will not vaccinate their child against rotavirus, 6% will not vaccinate against hepatitis A. (USA)
11% of doctors did not recommend their patients vaccinate their children with all vaccines.
Doctors-therapists did not recommend inoculation twice as often as pediatricians did (therapists earn less on vaccinations).
Doctors trust medical journals more than the CDC and the FDA. They trust pharmaceutical companies less than the Internet. (USA)
41% of nurses are not vaccinated against the flu. They were afraid of side effects, they believed that the risk of infection was low, and in general, they did not consider this vaccine to be effective. (USA)Skepticism towards Emerging Infectious Diseases and Influenza Vaccination Intentions in Nurses. 2017, Maridor, J Health Commun
Swiss nurses are skeptical of infectious diseases and the vaccine against influenza.
Outbreaks of diseases are always less dangerous than announced by public health authorities and the media, reducing public confidence in the reliability of expert sources of information. Conflict of interest between public organizations and private corporations also reduces public confidence.
Recent graduates of medical faculties less often believe that vaccines are the safest medicines, and that vaccines become better and safer. They are more resistant to compulsory vaccination, and they believe more that vaccination does more harm than good.Vitamin K prophylaxis for premature infants: 1 mg versus 0.5 mg. 2003, Costakos, Am J Perinatol
In preterm infants, the level of vitamin K on the second day after injection (0.5-1 mg) was 1900-2600 times higher than the usual level in adults, and on the tenth day - 550-600 times higher. of the vitamin in the group receiving 0.5 mg did not differ from the group receiving 1 mg.Are There Long-Term Consequences of Pain in Newborn or Very Young Infants? 2004, Page, J Perinat Educ
For many years, doctors in the US have not considered pain in infants as one of the risks or disadvantages in making treatment decisions. Surface observations showed that painkillers have some risks, and babies seem to still forget about pain, because if the patient does not come back with pain complaints, which can be particularly important?
However, studies in the 1990s revealed that pain experienced in infancy has long-term consequences: for example, babies who have been circumcised without lidocaine ointment suffered from pain during vaccination more than those cut off with lidocaine, which in turn suffered more than uncircumcised.
In newborn rats, which for some time were separated from the mother, suppression of the immune system was observed, and they were more
In rats, who were injected endotoxin in infancy, in adulthood there was an acute reaction to stress, increased susceptibility to metastases, and delayed healing of wounds, which indicates an inability to form a The rat pups, who were pained by puncture in the paw, showed increased pain sensitivity in adolescence. In adulthood, they showed great anxiety, social over-alertness, and they had a craving for alcohol.
Among those who refused to inject vitamin K, the majority were white (78%), over 30 (57%), and with academic education (65%), most of them also refused vaccination against hepatitis B and erythromycin ointments for the eyes.They, by and large, scooped up information from the Internet and were bothered by synthetic and toxic ingredients, excessive dose and side effects.
67% of them were aware of the risks of failure, but most did not understand the potential danger of bleeding, especially the risk of intracranial hemorrhage I and death.
The authors concluded that the information on the Internet on which parents are based is often not confirmed by referring scientific sources, and the percentage of injections is much higher. encourages natural births without medical intervention.The most important thing, the authors write, is that specific problems that are covered on websites on the Internet are not affected by doctors in their conversations with mothers.
Between 1998 and 2007, the incidence of meningococcal infection declined by 64%, on average over the years, the incidence was 1 per 200 thousand, and by 2007 the incidence of meningococcus decreased to 1 per 300 thousand.
The highest incidence was among infants less than a year (5 per 100,000), 50% of cases are caused by serogroup B. Two thirds of cases in the first year of life occur among infants younger than 6 months.
Blacks are 44% more likely than white. Mortality of meningococcal infection was 11%, and increased with age. The ratio was 24%, and among infants 3-6%.
Most cases were observed in January and February, and less in August.
The authors conclude that before the vaccination began, the incidence of meningococcal infection in the US was at historical the minimum, and that after the start of vaccination there was no significant reduction in the incidence in adolescents who were vaccinated, because only 32% were vaccinated.
(The motif, which runs the red thread in almost all studies. If after the start of vaccination there was no reduction in the incidence - then this is because the coverage was inadequate. And if there was a decrease, then, of course, this is due to vaccination, even if only 2% were vaccinated).
The risk of meningococcal infection in a child under 18 increases by 3.8 times if his mother smokes.
Among adults, smoking increases the risk of meningococcal infection by 2.4 times, passive smoking by 2.5 times, and chronic disease by 10.8 time.
The risk of meningococcal infection among homosexuals is 4 times higher than that of heterosexuals. HIV-infected homosexuals have a 10-fold higher risk of meningococcal disease than uninfected homosexuals. 45% of meningococcal cases reported numerous partners and participation in anonymous sex.
Among homosexuals, 32% smoke (compared to 18% of adults in the US), and 48% use drugs (compared to 10% on average).
In New York, the risk of meningococcal infection among homosexuals was 50 times higher than, on average, in German and 13 times above, in Paris 10 times above, in Southern California 50 times higher. 24% of homosexuals are carriers of meningococcus compared with 6% among heterosexual women, among the homosexuals who recently had oral-anal contact, 43% were carriers. Meningococcus was also detected in 4.5% of homosexuals in the anal channel. In 2016 there was a discovered a new strain of meningococcus that can be transmitted sexually.
CDC reports that in 2016, 57% of those meningococcal men over 16 years of age reported having a homosexual contact. More:   .
Outbreak of meningococcus at the University of Ohio (13 cases.) Visiting bars was associated with an 8-fold increase in the risk of the disease, and kissing more than one partner at 13.6.
In Chile, risk factors for meningococcal infection were tightness (more than 2.5 people in the bedroom), low mother education, low income, alcohol abuse and chronic illness.
In Brazil, a low level of education in parents is associated with increasing the risk of colonization 2 times, which probably reflects socioeconomic conditions.
In Greece, the tightness and previous ARI increased the risk of disease in children 3 times, and father's smoking 4.5 times. More:   
Clinical efficacy of Menacetra is 91% a year after vaccination, and in 2-5 years it decreases to 58% (CI: -72-89).High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine. 2017, McNamara, Am J Transplant
Eculizumab is a cure for very rare diseases, which suppresses the complement system (one of the components of the congenital immune system). This medicine is associated with an increased risk of a meningococcal infection 1000-2000 times.
16 people using this medication got meningococcemia, 14 of them were vaccinated.
At the beginning of 2015, there was an outbreak of meningococcal serogroup B infection at the College in Rhode Island (two cases), both recovered.
As a result of the outbreak, five vaccination campaigns were conducted with three doses for students and faculty on campus, and for their intimate partners, a total of ~4,000 newly licensed Truman vaccines were vaccinated.
Because it was not known how this vaccine affects colonization, the authors used a vaccination campaign to test it.
20-24% were meningococcal carriers, and 4% were carriers of serogram
Among the smokers, the risk of colonization has been increased by 30%, and among those who visit bars and clubs at least once a week, the risk of colonization has been increased by 80%. The authors concluded that vaccination does not affect in any way on the colonization of meningococcus and on collective immunity, and therefore a high vaccination coverage is needed.
Study of colonization of meningococcus at another university in Rhode Island.
Vaccination had no effect on colonization.
Smoking increased the risk of colonization by 1.5 times, and visits to bars at least once a week - 2 times.
As a result of the outbreak at the university in Oregon, a vaccination campaign was conducted, 11% -17% were carriers of meningococcus, 1.2% -2.4% of them were carriers of serogroup B. Vaccination 1-2 with Beksero doses and 1-3 Doses of Truman did not affect the colonization of meningococcus in general, and the colonization of serogroup B in particular.Guillain-Barré syndrome among the recipients of Menactra meningococcal conjugate vaccine - United States, June-July 2005. 2005, CDC, MMWR Morb Mortal Wkly Rep
Menacretra was licensed in January 2005, and was recommended for 11-12 year olds, as well as for first-year students.
Among vaccinated freshmen between June 10 and July 25, 2005, VAERS was registered 5 cases of Guillain-Barre syndrome.
In one case, the vaccinated girl had Guillain-Barre syndrome twice before, at 2 and 5 years, both times within 2 weeks after vaccination.
CDC conclude , that this may be an accidental coincidence, and it is recommended to continue the vaccination. The manufacturer added to insert that Guillain-Barre syndrome is possibly associated with vaccination.
Among those who received the inoculation from meningococcus (Menacultra/Menveo) together with other vaccinations, the risk of facial paralysis within 12 weeks after inoculation was 5 times higher compared to the control group. However, as a control group the same vaccinated, only 12 weeks after vaccination and further.
The risk of Hashimoto's disease in vaccinated people was 5.5 times higher, iridocyclitis 3.1 times higher, and epileptic seizure 2.9 times higher.And then all these cases were reviewed, some of them are excluded, and the authors concluded that statistically significant association between vaccination and these diseases do not exist.
From 3% to 11% of hospitalizations can be the result of side effects of drugs. Only 1% of serious side effects are reported to the FDA.
This leads to problems with drugs not being detected on time. , that silicone implants exist on the market for 30 years, only recently it turned out that they are associated with autoimmune diseases.
Active and passive smoking is associated with a doubling of the risk of tuberculosis. For smokers in the past and present increased the risk of contracting a tuberculosis bacterium, the risk of developing tuberculosis, the risk of complications, and the risk of dying from tuberculosis.
The risk of recurrent tuberculosis was 2-fold higher in smokers more than 10 cigarettes a day than non-smokers. More:    
In people with low weight, the risk of tuberculosis was 12 times higher compared to people with normal weight. In people who were overweight, the risk of tuberculosis was 3 times lower, and in obese people, it was 5 times lower. > In the 1950s, it was found that people with a reduced level of vitamins A and C were more likely to develop tuberculosis, and the addition of vitamins and minerals reduced the incidence in the families of patients. Since then, there has not been adequate research into the effect of nutrients on the risk of tuberculosis.Long-term results of BCG vaccination in the southern United States. 1966, Comstock, Am Rev Respir Dis
The study of the effectiveness of BCG in the United States, which lasted 14 years, the effectiveness of the vaccine was 14%, and among negroes the effectiveness was negative. Because of this study, it was determined that the effectiveness of BCG is too low, short-term and least effective among those, who has the highest TB risk, so BCG has never been introduced into the US vaccination calendar.Type A viral hepatitis: epidemiology, diagnosis, and prevention. 1997, Lemon, Clin Chem
70-80 people die each year from hepatitis A in the USA, and those are almost exclusively people over 50 years old. Severe cases of hepatitis A are more likely to occur in people with alcoholic liver disease or chronic hepatitis.
Some of the vaccinated people developed Guillain-Barre syndrome, but it is unclear whether this is due to vaccination.
Before the licensing of the vaccine, the incidence of hepatitis A in USA was approximately 1 in 10,000, and mortality rate was 1 in 3 million. In 1999, vaccination was introduced in 11 states, where the incidence was higher than 1 in 5,000.
In 2006, the vaccine was added to the national immunization schedule. Hepatitis A incidence at that moment was 1 in 100,000, and mortality rate was 1 in 10 million; and almost all lethal cases were in people over 50 years of age with comorbidities.
In 2001, the advisory committee of San Diego (California) emphasized the need to increase the number of public toilets in the city center.
In 2010, a plan to finance these toilets was developed.
In 2016, two toilets were installed. One of them was later closed due to operating costs and concerns about crime, and only one toilet remained open in 2017. Altogether, there were 8 public toilets in San Diego, but only three of them were available 24 hours a day.
In San Francisco, where the number of homeless people is comparable to San Diego, there are 25 public toilets and they are all open 24 hours a day.
In 2017, a hepatitis A outbreak began in the USA, affecting mainly homeless people of San Diego, where more than 500 people got sick and 20 people died. Thus, 16 portable toilets were opened.
Due to the fear of hepatitis A, the authorities arrest those who distribute food to homeless people in San Diego suburbs.
Development of rotavirus vaccine began in the 90s, so the CDC began to wonder, who many kids die from it. They conducted the following studies on this question:
Death from diarrhea (for any reason) makes up 2% of all post-neonatal mortality rates. In 1983, an average of 500 children died of diarrhea in USA in a year, 50% of them died in hospitals. Diarrheal death rate decreases drastically with age – it is twice as high for infants at the age of 1-3 months, as at the age of 4-6 moths, and 10 times higher than for 12-months-olds.
Risk of diarrheal death is 4 times higher for black people (and in some states 10 times higher) than for white people; 5 times higher for infants whose mothers are younger than 17 years old; twice as high for those, whose parents are unmarried; 3 times higher for those, whose parents have not graduated from high school.
Diarrheal mortality rate is higher in winter than in summer, and it is believed that the rotavirus is responsible for that. It is estimated that 70-80 children die each year from rotavirus.
Diarrheal death rate in the USA decreased by 75% (79% among infants) and stabilized between 1968 and 1985. 300 people (240 of them children) died of diarrhea each year between 1985 and 1991. Mortality rate among children was 1:17,000. From 1985, half of the children died at the age under 1.5 months (that is, before the vaccination age).
Here’s a graph of diarrheal mortality rate from 1968 to 1991.
Every winter it is possible to observe death peaks that disappear in the mid-1980s, and only small peaks remain in the group of 4-23 month old children. As rotavirus is affected almost and exclusively in the winter, the authors believe that those peaks are deaths from rotavirus.
The authors conclude that a vaccine against rotavirus will have a measurable but small impact on mortality from diarrhea.
It is estimated that 873 thousand people die from rotavirus each year around the world. However, there was no information on mortality rate of rotavirus in developed countries, and so in 1985 IOM concluded that this vaccine is not a priority for the USA. However, they used one prospective study as a basis, even though other studies determined that one third of children hospitalized with diarrhea had rotavirus infection.
Since not a single child in the USA died with a rotavirus diarrhea diagnosis, many pediatricians believed that rotavirus is never severe or lethal. However, mortality data analysis (in the previous studies) provided convincing, albeit circumstantial proof, that rotavirus can be lethal.
On the basis of two previous studies, the authors estimate that 55,000 children are hospitalized due to rotavirus each year, and 20 children die, i.e. 1 in every 200,000. They believe that these children also had some other disease, or they were premature, for example.
The authors conclude that less than 40 children each year die of rotavirus, although they never explain how they came up with the number ‘40’, since they only counted 20 in the body of article.
CDC claims that 20-60 children die of rotavirus each year, but they do not explain where they got ‘60’ from, since their own studies only got 20.
Rotavirus vaccination in the USA will prevent 63% of all rotavirus cases, and 79% of all serious cases, thus preventing 13 deaths and 44,000 hospitalizations per year.
If the price of the vaccine dose is more than $12, vaccination will not be economically feasible, and at the price over $42, it will not be justifiable from the societal point of view either. Today, RotaTeq costs $69-$83 per dose, and Rotarix is $91-$110 per dose.
Despite the obvious benefits of vaccination, no vaccine is completely safe. Post-clinical studies have shown that recently licensed rotavirus vaccine increases the risk of intussusception. However, it is unknown what risk would be acceptable to the parents, and how much they would be willing to pay for this vaccine.
To reach the 50% vaccination coverage, the parents are ready to allow 2,897 cases of intussusception per year, which would cause 579 surgeries and 17 additional lethal cases. And to achieve 90% coverage, the parents are ready to allow no more than 1,794 cases of intussusception per year, including 359 surgeries and 11 deaths due to vaccine.
Without rotavirus vaccine 20 children die.
The lower the parents’ income, the higher the risk they are willing to accept.
The parents are willing to pay $110 for three doses of risk-free vaccine, but only $36 for three doses or risky vaccine.
Other studies already determined that parents prefer death from disease, rather than from vaccine, and this study confirms this fact.
Two-months-old girl was vaccinated with Rotarix in Japan, and in 10 days her two-years-old sister was hospitalized with severe gastroenteritis. It turned out that her sister infected her with a mutated vaccine strain of the virus.
A similar case with a RotaTeq vaccine in the USA is reported here. Vaccinated infant infected his brother 10 days post-vaccination with a rotavirus strain that was reassortant of two vaccine strains.
Unvaccinated children are mostly white. Their mothers are over 30, married, have an academic degree, and their families earn more than $ 75,000 a year. (USA)Effects of Maternal and Provider Characteristics on the Up-to-Date Immunization Status of Children Aged 19 to 35 Months. 2007, Kim, Am J Public Health
The lower the mother's level of education, and the poorer, the higher the chance that she fully vaccinates her children.
More African and Latin Americans are vaccinating their children, and the poorer they are, the more they vaccinate. (USA)
Parents who do not vaccinate their children, value scientific knowledge, know where to look, and how to analyze information about vaccinations, and at the same time do not really trust medicine. (USA)Sociodemographic Predictors of Vaccination Exemptions on the Basis of Personal Belief in California. 2016, Yang, Am J Public Health
The number of non-medically refused vaccinations in California increased 4-fold between 2001 and 2014 (from 0.77% to 3.15%).
In private schools, there were twice as many refusals as in public schools. The percentage of refusers was higher among white, richer and more educated people.
In other states the same is observed - the percentage of those who refuse vaccinations in private schools is much higher than in public.
Parents with higher education and conservatives rarely allowed their daughters to get vaccinated against HPV. Parents who did not finish school, Catholics and liberals more often allowed their daughters to have this vaccination. (California, United States)Maternal characteristics and hospital policies for risk factors for nonreceipt of hepatitis B vaccine in the newborn nursery. 2012, O'Leary, Pediatr Infect Dis J
More educated mothers and mothers with higher incomes often refuse to vaccinate their newborn child against hepatitis B. (Colorado, USA)Live attenuated varicella vaccine: evidence that the virus is attenuated and the importance of skin lesions in transmission of varicella-zoster virus. National Institute of Allergy and Infectious Diseases Varicella Vaccine Collaborative Study Group. 1990, Tsolia, J Pediatr
Vaccine strain of the virus is produced by sequential passages through animal cell cultures, which attenuates the virus. But how can one be sure that this procedure truly attenuates the virus?
The hypothesis that chickenpox and shingles are caused by the same virus was proposed in 1909. To test it, researchers extracted fluid from the blisters of shingles patients, and injected it to children who have not been exposed to varicella, in 1925 and 1932. 50% of the children got infected with chickenpox, but the rash was less severe than usual. That is, if an airborne virus is administered by injection, it causes an atypical disease. Therefore, it is impossible to conclude that the vaccine strain of the virus is attenuated, only on the basis of it having caused mild symptoms. It is also possible, that the injected dose of the virus was not enough to cause the usual symptoms.
In this study, the authors vaccinated children with leukemia and examined how often they infected their healthy siblings. It turned out that only 17% of the siblings got infected. Since the wild strain of the virus infects 80%-90%, the authors concluded that the vaccine strain indeed is attenuated.
Varicella outbreak in daycare, where 66% of children had been vaccinated.
Vaccine efficacy was 44%. After three years the effectiveness decreased by 2.6 times. Vaccinated children had less rash than those unvaccinated.
The outbreak began with a vaccinated boy, who infected half of his class, who had no previous varicella exposure. The boy himself got infected by his 11 years old sister, who was suffering from shingles.
Vaccine efficacy was much lower than was determined during clinical trials. That is, most probably, due to the fact that in clinical trials, children who did not develop antibodies got repeat vaccination or were excluded from the efficacy analysis, or were analyzed separately, which is what led to an overestimated effectiveness rate.
Here is a meta-analysis of 14 studies of chickenpox outbreaks. The effectiveness of one dose was 72.5%.
Varicella outbreak in a school, where 97% of children had been vaccinated (with one dose). Vaccine effectiveness was 72% (CI:3-87). Children vaccinated over 5 years prior to the outbreak got infected 6.7 times more often than those vaccinated less than 5 years ago. More: , , .An outbreak of varicella in elementary school children with two-dose varicella vaccine recipients - Arkansas, 2006. 2009, Gould, Pediatr Infect Dis J
Varicella outbreak in a school, where 97% of children had been vaccinated (39% of them with two doses). The effectiveness of one dose and two doses was almost the same.Measles, mumps, rubella, and varicella combination vaccine: safety and immunogenicity alone and in combination with other vaccines given to children. Measles, Mumps, Rubella, Varicella Vaccine Study Group. 1997, White, Clin Infect Dis
After the MMRV vaccine, much less varicella antibodies are produced than after a separate vaccine, but more measles antibodies, as compared to MMR. .Herpes zoster ophthalmicus: declining age at presentation. 2016, Davies, Br J Ophthalmol
Herpes zoster ophthalmicus (HZO) accounts for 15% of all herpes zoster cases.
The number of HZO cases in Boston increased by 2.7 times between 2007 and 2013. The average age of patients decreased from 61.2 to 55.8 years, while the number of patients at the clinic during the same years has not changed.
The same was found in another study in Oklahoma, where the average age of HZO patients decreased by 8 years, from 65.5 to 58.9 years. Smokers got sick 11.5 years earlier than non-smokers.
The incidence of varicella in Massachusetts decreased by 79% between 1998 and 2003, but the incidence of herpes zoster increased by 90%, and 161% in the 25-44 years age group.
The incidence of herpes zoster in Minnesota increased by 28% between 1996 and 2001.
The incidence of herpes zoster among children under 10 years of age in California decreased by 55%, but increased by 63% among teenagers of 10-19 years of age.
The incidence of varicella fell 4-fold, and hospital costs associated with it decreased by $100 million per annum. However, hospital costs associated with herpes zoster increased by $700 million per annum by 2004.Herpes zoster at the vaccination site in immunized healthy children. 2018, Song, Pediatr Dermatol
Some children develop shingles at the vaccination site several years after vaccination.Postlicensure safety surveillance for varicella vaccine. 2000, Wise, JAMA
It is usually argued that vaccines are completely safe and that serious side effects occur in one in a million vaccinated individuals. How is such statistics obtained? Here is an example for chickenpox.
The authors (from FDA and CDC) analyze VAERS from 1995 to 1998. 14 deaths were recorded in this period. To calculate the probability of death after vaccination, they use the number of vaccines sold for this period (9.7 million), and conclude that the probability of death is 1 in one million (they round it up a little, as in fact it come up to 1 in 700,000).
It does not take into account that:
1) Only 1%-10% of all side effects get registered with VAERS.
2) The number of vaccine doses sold does not equal to the number of doses administered. Moreover, 9.7 millions doses sold is not an exact figure, but a CDC estimate.
A total of 6,574 adverse events have been registered with VAERS, 4% of which were serious. However, among children under 4 years of age there were 6.3% serious adverse events, among children under 3 years of age – 9.2%, and among children under one year of age, who got vaccinated by mistake – 14%.
A total of 271 serious adverse event have been registered, that is, 1 in every 36,000. These figures should be multiplied by 10-100 (that is, the real number is between 1:3600 and 1:360), and considering that the quantity of administered doses was lower than the quantity of sold doses, which is quite possibly overestimated, they should be multiplied by an additional factor.
In the US, the incidence of invasive pneumococcal infection among children under the age of 6 is 3-6 times higher than in Europe, it is also higher than in Australia and New Zealand. This is most likely because The US takes the blood for bacterial analysis in all children under the age of 3 with a temperature of 39 and above, and in all who have elevated white blood cells (they are also given antibiotics), and in Europe such analysis is usually done only hospitalized. As most cases of invasive pneumococcal infection is a temporary bacteremia that does not require gospi in Europe they are, for the most part, not diagnosed.Invasive pneumococcal disease in Dallas County, Texas: results from population-based surveillance in 1995. 1998, Pastor, Clin Infect Dis
People with low incomes get pneumococcal disease 2 times more often than people with middle income, and 3 times more often people with high incomes.Invasive pneumococcal infection in Baltimore, Md: implications for immunization policy. 2000, Harrison, Arch Intern Med
Blacks suffer pneumococcus 3.3 times more often white, and 40-49 year-old negroes - 12 times more likely. Median age of patients among blacks is lower than among whites at age 27.
Low-income people get sick more often. are sick more often than the inhabitants of the suburbs.
Almost 50% of Negroes infected with HIV AIDS increases the risk of pneumococcal infection by 100-300 times.
The authors conclude that it is necessary to vaccinate young and poor people living in cities, that the pneumococcus is mainly affected by blacks, it is necessary to vaccinate whites too, because among white people too be poor. But since the vaccination of risk groups was tested with hepatitis B and failed, the authors believe that there must be a universal vaccination against pneumococcus.
In 1994, 22.6% of pneumococcal pneumonia in the US was accompanied by complications, in 1999 there were already 53% of pneumonia with complications.Rising rate of pneumococcal bacteremia at the Children's Hospital of Philadelphia. 1994, Foster, Pediatr Infect Dis J
Five years after the start of Hib vaccination, the incidence of pneumococcal bacteremia in Philadelphia has doubled (from 38 to 73 cases per year). The incidence of hemophilic bacteremia has decreased from 34 to 9 cases per year, and the incidence of meningococcal bacteremia has not increased The incidence of pneumococcal meningitis has increased by 50% (from 5.2 to 7.6 cases per year), the incidence of hemophilic meningitis has decreased from 18 to 5.6 cases per year, and the incidence of meningococcal meningitis has not changed (3 cases in year).Routine pneumococcal vaccination of children provokes new patterns of serotypes causing invasive pneumococcal disease in adults and children. 2013, Norton, Am J Med Sci
The incidence of invasive pneumococcal infection in children has declined by a factor of 2 between 1996 and 2010, but among adults it has risen by a third. Overall, the incidence has increased slightly (Huntington, West Virginia).Changing incidence of Hemophilus influenzae meningitis. 1972, Smith, Pediatrics
From the 1940s to the 1960s, the incidence of Hib in the US increased five-fold.Day care attendance and other risks factors for invasive Haemophilus influenzae type b disease. 1993, Arnold, Am J Epidemiol
Passive smoking is associated with an increased risk of Hib by 40%. Kindergarten - with a 2.9-fold increase in risk. BF - with a 50% reduction in risk. Blacks were 4.1 times more sick.A case-control assessment of risk factors for Haemophilus influenzae type b meningitis. 1993, Sherry, Eur J Pub Health
BF for more than a month is associated with a decrease in the risk of meningitis from Hib by 62%, BF for more than 9 months - with a decrease in risk by 88%. Kindergarten - with a risk increase of 2.6-4.7 times.Risk factors for invasive Haemophilus influenzae type b in Los Angeles County children 18-60 months of age. 1992, Vadheim, Am J Epidemiol
An analysis of all cases of Hib in Los Angeles in 1988/9 (8.7 million people, of whom 750,000 are children under the age of 5).A total of 88 cases were recorded among children during the year, with a lethality rate of 4.5%.
Risk Hib in children in homes where more than 2 smokers live was six times higher.
Six or more people living in one house are associated with an increased risk of Hib 3.71 times Negroes are 3.47 times more likely to suffer and also increase the risk of chronic disease and low income.
Vaccination and breastfeeding (in white) reduce the risk of Hib.Vac vaccination with a polysaccharide vaccine increased the risk of Hib.
In another iss The study found that the smoking parent increased the Hib risk by 2.37 times.
Before the vaccination, the Eskimos in Alaska hurts Hib is 10 times more likely than other US residents.
Australian aborigines, Indians, Eskimos and Africans in the Gambia and Somalia sick are 3-4 times more likely than Americans and 10 times more likely than Europeans.
Polysaccharide vaccine from Hib was licensed in the US in 1985. In a clinical study in Finland, it was found that the vaccine is ineffective for children under 2 years old, and 80% effective from 2 to 3 years. Prior to licensing, the only US study among 16,000 children did not find that the vaccine was effective, so it was licensed based on a Finnish study only for children over 2 years of age (although most cases were in children under the age of one year.) Once the vaccine was licensed, randomize However, since Hib is a rare disease, it is still difficult to conduct such a study, as many participants are required.
In the observational study in Minnesota, it turned out that the effectiveness of this vaccine is negative and it increases the risk of the disease by 58% In other studies, it was found that the vaccine increases the risk of the disease in the first week after vaccination, and subsequently IOM also found that unconjugated vaccine from Hib increases the risk of the disease.
Before the vaccination, the incidence of Hib in Alaska was the highest in the world. Thanks to the vaccine, the number of Hib cases dropped sharply, but cases from other serotypes, mostly serotype A and noncapsular strainsIncreasing incidence of invasive Haemophilus influenzae disease in adults, Utah, USA. 2011, Rubach, Emerg Infect Dis
Vaccination reduced the number of Hib cases among children by 99%, but the incidence of hemophilic infection among adults increased 11.5-fold between 1998 and 2008. Most of the cases were in the serotype F and in the capsule-free strains.The mortality was 22%.The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons> or = 65 years old. 2007, Dworkin, Clin Infect Dis
Between 1996 and 2004, the number of Hib cases in Illinois increased by 2.5 times, and among the elderly by 3.5 times.
The number of cases of infection with HQ-free increased by 657%.If in 1996, Hib's bespaksulnaya was responsible for 17.5% of the cases, in 2004 it was responsible already in 70.7% of cases, the lethality was 12.7%, and among the elderly - 20.6%. The mortality of serotype F among the elderly was 11.1%, and the serotype E - 38.5%.
For a long time I doubted about the vaccinations from Hib and pneumococcus, because these diseases can really be dangerous.The fact that I personally put the final cross on these vaccinations was the following article published in a rather marginal journal specializing in hypotheses It seems that even for this marginal magazine, the article was too marginal, and accompanied by an editorial article in which they write that, despite , that the theme of the connection between vaccines and autism is already worn to holes and a denial bent, and that although the author of the article is not a scientist at all, his hypothesis is, nevertheless, quite plausible, and it should be checked.
I highly recommend reading this article in full.
Editorial article is also worth reading.
Conjugated vaccines radically change immunological response to carbohydrate antigens In the absence of a conjugated vaccine, carbohydrate antigens usually do not induce an immune response of T cells, but induce a weaker response (T-cell independent). This is due to the fact that B2 cells do not synthesize antibodies without the signal of T-helper cells. In order for this to happen, the B2-cell, and its related T-helper cell, should recognize the same, or similar epitope. But since T cells recognize only protein epitopes, T helper cells are usually able to activate B2 cells in response to protein antigens. In response to bacterial capsular polysaccharides, the immune system forms a response through cells B1 and MZB (Marginal zone B). B1 cells do not begin to react to bacterial carbohydrate antigens until 18-24 months, and their response does not fully mature until about 5 years of age. Therefore, infants and young children are unable to respond effectively to capsular bacteria. Conjugated vaccines use the fact that B2 cells and their related T helper cells do not have to respond to an identical epitope, but rather recognize closely related epitopes. Although the mechanisms by which conjugate vaccines work are not fully understood, it is believed that antigen-presenting cells, treat the combined protein carrier and carbohydrate hapten, which leads to recognition of the protein carrier by T-helper cells, and recognition of carbohydrate antigens by B2 cells. That is, conjugated vaccines change the immunological response to carbohydrate antigens in infants and young children, from a hypo-sensitive to a full T cell response.
Because antibodies against carbohydrate antigens are often autoreactive with their own carbohydrates, the differentiation of B cells to B2 cells can lead to an autoimmune reaction. Therefore, B cells against carbohydrate antigens are carefully regulated by the immune system. Antibodies to native carbohydrates are associated with several autoimmune diseases, such as systemic lupus erythematosus, myocarditis and rheumatic heart disease, Sydenham's chorea, and children's autoimmune neuropsychiatric disorders associated with Streptococcal infections (PANDAS).
Unlike antibodies produced by B2 cells, antibodies produced by B1 and MZB cells are short-lived and low-affinity, and conducted to an autoimmune reaction with
Autism has an increased level of antibodies to nervous structures and an increased level of proinflammatory cytokines in the brain, which indicates that autoimmune and neuroinflammatory processes can play a role in some cases of autism.
Because myelinization (the formation of an insulating nerve fibers) is most intense during the first 9 months of life, and continues in early childhood, neuronal development in infants and young children can be particularly vulnerable to self-reactive antibodies, including those that react with glycoproteins in myelin sheaths.
The first conjugate vaccine (from Hib) appeared in the US in 1988, and was later licensed in most other developed countries, including Denmark in 1993, and Izr ail, where it was licensed in 1992, and introduced into the national vaccination calendar in 1994.
The incidence of autism began to rise dramatically in the US since births in the middle of 1987. In Denmark and Israel, the jump in autism began about 5 years later.
In 1990, the vaccine was licensed to infants from the age of two months, which may explain the further increase in autism.Another explanation for the increase in autism in the mid-90s could be a change in the protein carrier used in the vaccine, which made her more immune gene. If the Hib vaccine is an autism trigger, then an increase in its immunogenicity and a change in the binding site may increase the likelihood of autism.
The licensing of the pneumococcal vaccine in 2000 may partially explain the further increase in autism. Children born in 1995 were the first to be vaccinated against pneumococcus, and this is consistent with CDC data, according to which the level of autism in 1992-1994 did not change, and in 1998 autism was already 57% higher than in 1994, m.
In Denmark, the Hib vaccine was licensed in 1993, but immediately followed by an aggressive vaccination campaign for children, starting in 1988, which coincides with the growth of autism among those born in 1988 and later. > In Israel, the number of children receiving disability benefits due to autism did not change from 1972 to 1995. But from 1996 to 1998, their number increased 5-fold, which is explained by this hypothesis. In 2004, 11% of the beneficiaries were born in 1985-89 (before vaccine licensing), 21.1% were born in 1990-94 (the beginning of vaccination), and 37% were born in 1995-99 (immediately after the vaccination was introduced National calendar). The immune system in response to the carbohydrate membrane of capsular bacteria produces antibodies through B1 and MZB cells in adults, and in children older than 5 years. But children under 5 years of age react poorly to carbohydrate antigens. Conjugated vaccines consist of a protein carrier attached to a carbohydrate antigen, and are able to circumvent this restriction of the immune system to carbohydrate antigens in children. Due to the protein carrier, these vaccines can induce the production of antibodies by B2 cells.
The development of antibodies to carbohydrate antigens via B2 cells is a significant departure from the natural paradigm in which B1 and MZB cells usually produce short-lived antibodies against carbohydrate antigens, and B2 cells produce more long-living against protein antigens. In addition to the fact that the immune system of children under 5 years of age reacts poorly to capsular bacteria, the maternal IgM and IgG2 antibodies do not pass well the placenta, from which it follows that the embryos are probably also not protected from capsular bacteria. From the point of view of evolution, this is quite unexpected. It is possible that this evolutionary flaw is accompanied by a compensatory evolutionary advantage. One possible explanation is that antibodies to carbohydrate antigens can be cross-reactive with neuronal glycoproteins, and a fine balance has been achieved, by evolution, between evolutionary protection against capsular bacteria and the need for development of the nervous system. This is consistent with the fact that myelination begins with infancy, and lasts until early childhood, which coincides with the period during which the immune system is hypo-sensitive to carbohydrate antigens. Moreover, the period during which the immune system is least sensitive to carbohydrate antigens corresponds to the period of the most intense myelination. It is possible that antibodies to carbohydrates not only interfere with the development of the nervous system in infants and young children, but their negative effects are strengthened by a stable a response of the immune system induced by conjugated vaccines, which significantly disturbs the balance achieved by evolution.
Many people believe that influenza vaccination can cause flu, the authors conducted this study to prove that it is not so.They found that: 1) The incidence of influenza among vaccinated and unvaccinated did not differ. 2) The incidence of other respiratory diseases among vaccinated children was 71% higher than that of unvaccinated children.Pandemic preparedness for swine flu in the United States. 2009, Edlich, J Environ Pathol Toxicol Oncol
Some health professionals may not want to be vaccinated against swine flu because the vaccine contains a mercury preservative thiomersal that can be harmful to health.It should check the level of vitamin D and make up for the deficit if necessary. the level of vitamin D is 50-75 ng/mL, and the optimal dose for adults is 4000-5000 IU per day.Active immunization against poliomyelitis. 1936, Brodie, Am. J. Public Health
During the epidemics of poliomyelitis in the 1930s, among children who did not have antibodies, only one child from 170 became ill.Laboratory data on the Detroit poliomyelitis epidemic-1958. 1960, Brown, JAMA
In 1958, there was a polio epidemic in Michigan (more than 1,200 cases), most of them in Detroit, 1,060 of them had blood tests and feces. Of those who had a feces analysis, 46% did not have viruses, 33% had poliovirus, 11% had echovirus, and 8% had Coxsackie virus. Of those who had a blood test, only 25% of paralyzed had a poliovirus. paralysis was not poliovirus.Coxsackies and echoviruses were responsible for more cases of non-paralytic poliomyelitis and aseptic meningitis than for iovirus. 11, paralyzed from polio patients have been vaccinated at least three doses.A conversation with Paul Meier. Interview by Harry M Marks. 2004, Meier, Clin Trials
The Cutter Incident, 50 Years Later (Offit, 2005, N Engl J Med)
During clinical trials IPV, Salk published an article in which he claimed that the entire virus in the vaccine was inactivated but did not provide data on all batches of the vaccine.Paul Meier (the same from Kaplan-Meier) believed that something with the data was unclean and that to deal with this, NFIP formed an advisory committee.When someone did not agree, he was expelled from the committee, and someone else was sought, more accommodating. reformed 5-6 times, until after everyone agreed.
After clinical trials, the NFIP gave the committee two hours to review the materials, after which the license for the production of the Salk vaccine was given to six companies.
Two weeks after the licensing, some children vaccinated with the vaccine Cutter Laboratories, were paralyzed, and the vaccine was withdrawn, but 380,000 children were already vaccinated. Subsequently, it turned out that 40,000 of them became ill with polio, 200 were paralyzed and 10 died, because the vaccine was not sufficiently inactivated and contained a living virus. The Wyeth vaccine also resulted in paralysis and death in some cases. Other companies also had difficulties with inactivating the virus. Too little formaldehyde did not kill the virus, but too much made the vaccine useless. And the remnants of various substances in the vaccine protected the viral particles from formaldehyde.
Because other vaccine manufacturers threatened newspapers that they would reduce the amount of advertising, it was decided to blame the whole blame on Cutter.
Despite the fact that Cutter's negligence was not proven, the court ordered her to pay compensation. Over time, this led to an abundance of lawsuits against vaccine manufacturers, which resulted in the adoption of a law in 1986 that it was impossible to sue vaccine manufacturers. Compensation since then can only be obtained by filing a lawsuit in a special federal court, which is funded by a tax on vaccines. However, one loophole remained. If the special court rejected the claim, then it could be submitted to the company in a regular court. The author (familiar to us already Paul Offit) believes that the loophole needs to be covered, since these courts are worth millions of dollars for companies, and are distracting them from the production of such important drugs.
An Institutional Outbreak of Poliomyelitis Apparently Due to a Streptococcus in Milk. 1932, Rosenow, J. Infect. Dis
The epidemic of poliomyelitis in 1930 (927 cases), it turned out that it was caused by raw milk in which "poliomyelitis streptococcus". As soon as the milk was no longer used, new cases ceased to occur. epidemics of poliomyelitis due to milk: , , , .DDT poisoning and elusive virus X; a new cause for gastro-enteritis. 1949, Biskind, Am J Dig Dis
In recent years, a new strange syndrome has appeared in the US, which is most likely caused by some kind of infection, which was called the "virus X". Syndrome is accompanied by acute gastroenteritis, nausea, vomiting, abdominal pain , diarrhea, runny nose, cough, sore throat, joint pain, muscle weakness, fatigue and paralysis.Afterwards it was found out that all these symptoms were caused by DDT Paralysis from DDT is similar to poliomyelitis. Although DDT is a fatal poison, it is considered completely safe in all doses.It is used in every home in unlimited quantities They are sprayed on the skin, on the bed and clothes, on food and on dishes, on agricultural crops and on cattle.DDT is a cumulative poison.Many small doses are also lethal, like one large dose.DDT can not be removed from food, it accumulates in fat cells, and is excreted in breast milk. The large-scale intoxication of the American population will certainly occur.The poison cause of poliomyelitis and obstructions to its investigation. 1952, Scobey, Arch Pediatr
- Here is an analysis of dozens of cases and polio outbreaks, in which paralysis was caused by lead poisoning, arsenic, mercury, cyanide, pesticides, carbon monoxide, etc.
It is also reported that vitamin C, which is effective treats poliomyelitis, was also used to treat poisonings.
A century ago, it was noticed that lemon juice protects from poisoning by fish, which sometimes led to paralysis, which is probably the reason that fish is usually served with lemon juice.
- Monkeys never infected each other with polyo myelitis.
Among other things it is reported that when animals were injected with aluminum hydroxide, they formed protein aggregates similar to infectious encephalitis.
- Previously observed epidemics of pellagra and beriberi, and therefore it was believed that these are infectious diseases. Because in 1911 poliomyelitis was introduced into the Public Health Law as a contagious and infectious disease, only virologists deal with it, and ordinary doctors can not participate in the research. Because of this, no studies are also being conducted, whether poisoning can be the cause of poliomyelitis. Such studies are not funded.
In 1921, Franklin Roosevelt, who later became president of the United States, was diagnosed with polio. Roosevelt founded the March of Dimes (NFIP) organization, which funded the creation of polio vaccine and the treatment of the disease, no one doubted his diagnosis The times of any paralysis were polio.
In this article the authors analyze in detail the historical evidence of Roosevelt's symptoms, make a Bayesian analysis of each symptom, and conclude that according to three different methods of analysis, Roosevelt most likely had a syndrome th Guillain-Barre syndrome, not poliomyelitis.
The previous article, of course, was sharply criticized, historians and neurologists did not want to lose the poliomyelitis president. In this article, the authors respond in detail to the published criticism, and conclude that in the 13 years that have passed since the publication of their article, No alternative analysis of Roosevelt's disease was published, and that historians and doctors continue to believe in Roosevelt's polio because of confirmation bias and appeal to authority, and also because Guillain-Barre destroys the beautiful history of poliomyelitis, in which Roosevelt's disease is logically linked to his leading role in the victory over poliomyelitis.Mumps meningoencephalitis 1957, Bruyn, Calif Med
Here is the report of 119 cases of meningoencephalitis caused by mumps in San Francisco in 12 years (1943-1955). Most cases are mild, with no complications, no neurological consequences, last less than 5 days, and rarely require hospitalization. Death due to mumps meningoencephalitis is a very rare phenomenon, and in the entire medical literature only 3 such cases have been described (including one out of these 119).Mumps in the workplace. Further evidence of the changing epidemiology of a childhood vaccine-preventable disease. 1988, Kaplan, JAMA
20 years after the invention of the vaccine and 10 years after it became widely used, the first mumps outbreak (118 cases) occurred in the workplace (Chicago Futures Exchange). Total costs associated with the outbreak amounted to $120,738, whereas the vaccine costs only $4.47.
The authors report that historically, vaccine prevention of mumps did not get as much attention as the other diseases, because it is a mild one. However, $1,500 per case of mumps is too expensive, when the vaccine only costs $4.47 in public and $8.80 in private sectors. Research shows that every dollar invested in the mumps vaccine, saves $7-$14.
In addition, mumps in adults often leads to complications. 10-38% of post-pubertal men get orchitis. Also, mumps patients often develop meningitis (0.6% of cases among those aged 20 years or more). Getting mumps during the first trimester of pregnancy increases the risk of miscarriage.
In pre-vaccination times, mumps outbreaks were observed mainly in prisons, orphanages and army barracks.
84% of men and 89% of women in Minnesota had diphtheria antibodies level below 0.01 IU/ml.Serologic Immunity to Diphtheria and Tetanus in the United States. 2002, McQuillan, Ann Intern Med
40% of Americans do not have sufficient immunity to diphtheria (below 0.1 IU/ml).An Outbreak of Diphtheria in Baltimore in 1944. 1945, Eller, Am J Epidemiol
Diphtheria outbreak in Baltimore. 103 cases were recorded in 1943. 29% of the patients have been vaccinated, and another 14% claimed that they have also been vaccinated, but had no documented proof.
Consequently, they started to vaccinate more in Baltimore. In the first half of 1944, 142 cases were already recorded. 63% of them have been vaccinated.
The researchers ran blood tests of 104 California residents. Agglutinins to several strains of tetanus bacteria were found in the blood of 80% of them, but they did not have antibodies. The authors believe that tetanus bacteria were in the intestines of these people in the past, but did not survive there and thus they do not have the antitoxin.
Tetanus agglutinins have not been researched since then.
In four years from 1922 to 1925 in California, 245 cases of tetanus have been recorded. Mortality rate was 67%.
Among the 530 people in the study, the authors found bacteria in the intestines of 24%. They believe that the presence of tetanus bacteria in the intestines depends on the microflora, since they have always seen other types of bacteria along with tetanus bacteria, and did not see other bacteria, when the tetanus bacteria were absent.
70% of Americans had protective levels of tetanus antibodies (0.15 IU/ml). The children had protective levels higher than 80%, but much lower than the vaccination coverage (96%). Less than 5% of parents refused vaccination, meaning that refusing vaccination is not a significant factor for the absence of antibodies in the USA.
It is reported here that in tetanus vaccinated animals, TTC (non-toxic fragment of tetanus toxin) reached the brain in the same amount as in the unvaccinated animals.
As in the case with whooping cough, it is argued that the vaccine is responsible for reducing the incidence of tetanus by 92%, and the mortality rate by 99%.
This article analyzes cases of tetanus in USA since 1900 and shows a graph, according to which, the mortality rate decreased by more than 95% even before the vaccination began in the late 40s.
The risk of contracting pertussis after the fifth dose of the vaccine increases every year by 42%, and after five years the vaccine is already ineffective (assuming an initial effectiveness of 95%). Out of all the pertussis-affected children in northern California, none have been hospitalized, and none have died. More: .Prevalence of Antibody to Bordetella pertussis Antigens in Serum Specimens Obtained from 1793 Adolescents and Adults. 2004, Cherry, Clin Infect Dis
Among 1,800 adolescents and adults, only 20% had antibodies against the pertussis toxin one month after vaccination. Antibodies to other vaccine antigens were found in only 39-68% of the subjects.Unexpectedly limited durability of immunity following acellular pertussis vaccination in preadolescents in a North American outbreak. 2012, Witt, Clin Infect Dis
During the whooping cough epidemic of 2010, the majority of cases were children aged between 8 and 12 years old. There was no difference in the incidence between vaccinated, under-vaccinated and unvaccinated children (2 to 12 years).Possible temporal association between diphtheria-tetanus toxoid-pertussis vaccination and sudden infant death syndrome. 1983, Baraff, Pediatr Infect Dis
The DTP vaccine has been associated with sudden infant death syndrome (SIDS) in Los Angeles, and visits to the doctor have also been associated with SIDS.Risk of Nontargeted Infectious Disease Hospitalizations Among US Children Following Inactivated and Live Vaccines, 2005-2014. 2017, Bardenheier, Clin Infect Dis
In USA, the risk of hospitalization among children whose last vaccine was a live one was twice lower than for those who received the inactivated vaccine as their last one.Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants. 2000, Stajich, J Pediatr
Концентрация ртути в крови у недоношенных младенцев повысилась в 13.6 раз после прививки от гепатита В (с 0.54 до 7.36 мкг/л).
У доношенных младенцев концентрация ртути повысилась в 56 раз (с 0.04 до 2.24 мкл/л).
Первоначальный уровень ртути у недоношенных был в 10 раз выше, чем у доношенных (нет статистической значимости), что намекает на более высокий материнский уровень ртути у недоношенных.
Хотя согласно нормативам HHS (Health&Human Services), нормальным уровнем ртути в крови считается 5-20 мкг/л, в опубликованной литературе имеются расхождения насчет того, какие уровни считаются токсичными, а какие нормальными. Более того, эти данные были получены от взрослых, которые подвергались воздействию ртути на производстве.
Вакцина от гепатита В с тиомерсалом ассоциирована с повышенным в 2 раза риском задержек развития. У тех, кто получил 3 дозы такой вакцины, риск задержек развития был в 3 раза выше, по сравнению с теми, кто получили вакцины без тиомерсала.
Эта же вакцина ассоциирована с десятикратным увеличением потребности в особом образовании у мальчиков.
Чем выше в штате концентрация ртути в воздухе, тем выше в нём риск аутизма.Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. 2006, Palmer, Health Place
В Техасе, на каждые 1000 фунтов выделеления ртути в атмосферу в школьном округе, количество детей на специальном образовании возрастало на 43%, а количество аутистов возрастало на 61%.
В городах количество аутистов было на 437% выше, чем в сельской местности; а в пригородах на 255% выше, чем в сельской местности.
В другом исследовании сообщается, что на каждые 1000 фунтов выделения индустриальных отходов количество аутистов увеличивается на 2.6%, а если эти отходы от электростанций, то количество аутистов увеличивается на 3.7%.
Каждые 10 миль расстояния от индустриальных источников ртути или электростанций ассоциированы со снижением количества аутистов на 2% и 1.4% соответственно. Еще:   
Авторы проанализировали VAERS и обнаружили, что у младенцев, которые получили вакцину DTaP с тиомерсалом риск аутизма был в 2 раза выше, чем среди получивших вакцину без ртути.
В анализе Vaccine Safety Datalink (VSD), другой базы данных, обнаружилось, что вакцина от гепатита В с тиомерсалом ассоциирована с повышенным риском аутизма (OR=3.39).
Привитые от гепатита В новорожденные мальчики имели в 3 раза больший риск развития аутизма, по сравнению с непривитыми, или привитыми хотя бы через месяц после рождения.
Вакцина от гемофильной инфекции с тиомерсалом ассоциирована с повышением риска аутизма в 2.75 раз, задержки развития в 5.39 раз, психомоторных нарушений в 2.38 раз и неврологических расстройств в 2.7 раз по сравнению с привитыми вакциной без тиомерсала.Possible temporal association between diphtheria-tetanus toxoid-pertussis vaccination and sudden infant death syndrome. 1983, Baraff, Pediatr Infect Dis
Вакцинация DTP и визиты к врачу ассоциированы с СВДС в Лос-Анджелесе. 6 из 27 младенцев умерли в течение 24 часов после прививки, и 17 умерли в первую неделю после прививки.
Это исследование подверглось критике, поскольку, по мнению автора, не учитывает, что период повышенного риска умереть от СВДС совпадает с периодом, когда младенцам делают прививки, а потом резко падает. Поэтому, возможно, так случайно совпало, что младенцы чаще умирали именно в первый день, и в первую неделю после прививки.
До начала современных программ вакцинации "смерть в колыбели" встречалась настолько редко, что она не упоминалась в статистике младенческой смертности. В США национальные кампании вакцинации были начаты в 1960-х годах. Впервые в истории, большинство американских детей должны были получать по несколько доз вакцин, а вскоре после этого, в 1969 году, появился новый медицинский термин - синдром внезапной детской смерти. К 1980-му году СВДС стал основной причиной постнеонатальной смертности.
В 1992 году Американская академия педиатрии, начала кампанию "Back to sleep", которая убеждала родителей укладывать детей спать на спину, а не на живот.
В период с 1992 по 2001 год уровень СВДС снижался в среднем на 8.6% в год. Однако другие причины неожиданной детской смерти (SUID - sudden unexpected infant death) увеличились.
Например, младенческая смертность от удушья в постели увеличилась в среднем на 11.2% в год. Младенческая смертность от удушья по другим причинам, а также смертность от других причин тоже увеличились. В других исследованиях были аналогичные наблюдения.
Анализ данных с 1999 по 2001 год показывает, что уровень СВДС продолжал снижаться, однако значительного изменения в общей постнеонатальной смертности не произошло.
Хотя в некоторых исследованиях не удалось найти корреляцию между СВДС и вакцинами, имеются свидетельства того, что некоторые младенцы более восприимчивым к СВДС после вакцинации. Например, Torch обнаружил, что две трети младенцев, умерших от СВДС, были вакцинированы DTP. Из них 6.5% умерли в течение 12 часов после вакцинации; 13% в течение 24 часов; 26% в течение 3 дней; a 37%, 61% и 70% в течение 1, 2 и 3 недель, соответственно. Torch также обнаружил, что непривитые дети умирали от СВДС чаще всего осенью или зимой, тогда как привитые чаще всего умирали в 2 и 4 месяца - то есть тогда, когда младенцев впервые прививают DTP. Он заключает, что риски вакцинации могут перевесить ее потенциальную выгоду.
Вот данные CDC. Уровень СВДС в США с 1992 года значительно снизился, однако если считать все неожиданные смерти вместе, то их уровень снизился на 30% к середине 1990-х, и с тех пор практически не меняется.
Индейцы и афроамериканцы умирают от внезапных причин в 2 раза чаще белых, и в 5 раз чаще азиатов.
Смертность младенцев от удушья в кровати с 1990-х увеличилась более чем в 10 раз, несмотря на то, что рекомендация укладывать детей на спину должна была в первую очередь привести к снижению случаев удушья. CDC, почему-то, никак не комментирует этот факт.
В Австралии то же самое - хотя количество СВДС снижается, количество смертей от удушья увеличивается. Еще: 
18-месячного ребенка привили MMR, несмотря на то, что он был больной. Он умер через 10 дней. Патологоанатом установил, что смерть ребенка не связана с прививкой, так как его симптомы появились слишком быстро после вакцинации, чтобы быть с ней связанной, и ребенок просто умер от СВДС.
В 2011 году здоровый четырехмесячный младенец в США получил 7 вакцин, а на следующий день умер с диагнозом СВДС. В июле 2017-го, суд решил, что вакцины сыграли существенную роль в смерти мальчика, и без их влияния он бы не умер.Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children. 2017, Mawson, JTS
Нет, не совсем так. На самом деле одно исследование, сравнивающие привитых и полностью непривитых, всё же было опубликовано в 2017 году, и в нем обнаружилось, что привитые заболевают аутизмом в 4 раза чаще непривитых.
У этого исследования много недостатков. Оно было ретроспективным, основанным на анонимных опросах, и в нем участвовали лишь 405 привитых и 261 непривитых детей на домашнем обучении. Однако других подобных исследований пока еще не проводилось.
Авторы проанализировали 1300 рассмотренных в суде случаев компенсации ПВО, и обнаружили, что несмотря на то, что официально вакцины не вызывают аутизм, и коллективный иск был отклонен, как минимум в 83 случаях компенсация была выплачена аутистам. Большинство судебных дел с выплатами компенсаций засекречены, поэтому для обнаружения этих случаев была создана группа, которая обзванила людей, обратившихся в вакцинный суд.