Puzzling associations between childhood infections and the later occurrence of asthma and atopy. 2000, von Hertzen, Ann Med

According to some studies, systemic infections such as measles, hepatitis A and tuberculosis infections prevent allergies and asthma. This is explained by the fact that some bacterial and viral infections shift the immune response towards Th1.
BCG vaccination, however, does not prevent allergies and asthma.

Hepatitis A

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. 1997, Matricardi, BMJ

Recruits in Italy, who had antibodies for hepatitis A, suffered from asthma and allergic rhinitis 2 times less often, than the soldiers who did not have antibodies. Recruits, who had older brothers, also suffered from allergic diseases less frequently, which means that hepatitis A is not the only infection that decreases the risk of allergic diseases.
Hepatitis A was an endemic disease in Italy in the 1970s. It was usually an asymptomatic childhood disease.
Other studies in recent decades also reveal an inverse relationship between hepatitis A antibodies and allergies in different countries. In the 1970s in the USA, hepatitis A antibodies were more often detected in the older generation than in the younger one, whereas younger generation had more atopic diseases.

Hepatitis A

The prevalence of atopy in children with antibodies against hepatitis A virus and hepatitis B virus. 2006, Kocabaş, Turk J Pediatr

Children who did not have hepatitis A antibodies suffered from asthma and allergic rhinitis 9 times more often. Those who did not have hepatitis B antibodies suffered from allergic diseases 5.9 times more often. More: [1].


The concept of allergies was unknown until 1906. It was invented by an Austrian pediatrician and used to describe the strange symptoms he observed in those who received the diphtheria immunoglobulin.
The concept of anaphylactic shock also did not exist until 1902.


Aluminum hydroxide is used to stimulate allergies in mice.
Intracerebral injections of aluminum hydroxide cause epilepsy in monkeys.


Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year old U.S. children. 2017, Mawson, JTS

The study compares homeschooled children in four states of the USA. 405 vaccinated and 261 unvaccinated children.
Acute diseases:
Vaccinated children had chicken pox 4 times less often, whopping cough – 3 times less often and rubella – 10 times less often.
Vaccinated children had otitis media 4 times more often and pneumonia – 6 times more often.
Chronic diseases:
Those vaccinated had allergic rhinitis 30 times more often. They had allergies 4 times more often, ASD – 4 more often, ADHD – 4 times more often, eczema – 3 times more often, learning disabilities – 5 times more often, neurological disorders – 4 times more often. Vaccinated children had any type of chronic illness 2.5 times more often.
Vaccinated children used allergy medicines 21 times more often, antipyretics – 4.5 times more often, ear-drainage tubes – 8 times more often. They went to see a doctor, due to illness, 3 times more often and were hospitalized 1.8 times more often.
Some more interesting results from this study: risk of neurological disorders associated with the use of antibiotics during pregnancy (2.3 times), use of medicine during pregnancy (2.5 times), prematurity (5 times), ultrasound (1.7 times), and ultrasound done more than 3 times during pregnancy – 3.2 times.
The number of neurological disorders in vaccinated children (14.4%) coincides with the CDC studies (15%). The number of learning disabilities also coincides (5.6% of the vaccinated children in this study, and 5% according to available statistics).
However, judging by this study, there is already 3.3% of autistic children among vaccinated, i.e. 1 in 30 children. But, perhaps, it is an overestimation, as it is likely that children with ASD are homeschooled more often. (According to the CDC 2.24% of children are with ASD, i.e. 1 in 45 in 2015 and 1 in 36 in 2017).
Vaccination of a premature baby is associated with a 14 times increase in the risk of neurological disorders.


Is infant immunization a risk factor for childhood asthma or allergy? 1997, Kemp, Epidemiology

New Zealand, 23 unvaccinated (against DTP and Polio) out of 1,256 10-year old children. Out of the vaccinated children 23% had asthma, 22% got consults on asthma, and 30% had allergies.
There wasn’t a single case of asthma, or consults on asthma, or allergies among the unvaccinated children.


Vaccination and Allergic Disease: A Birth Cohort Study. 2004, McKeever, Am J Public Health

A study of 30 thousand children from the UK.
Children vaccinated against diphtheria/tetanus/pertussis/polio had asthma 14 times more often and eczema – 9 times more often than unvaccinated children.
Children vaccinated against measles/mumps/rubella had asthma 3.5 times more often and eczema – 4.5 times more often.
The numbers seem to speak for themselves, right? But these figures do not suit the authors, as they want to justify vaccinations. So they do two sleights of hand.
First, they determined that unvaccinated children visit doctors less. In their opinion, this does not mean that unvaccinated children get sick less often, but rather that their chance of being diagnosed is lower than of those vaccinated! Therefore, they make a correction. It turns out not to be enough, however.
They go further and divide all children into 4 groups by the number of visits to the family doctor, and then analyze each group separately. And, oh miracle, statistical significance among those who go to the doctors often disappears! But among those who went to see doctors less then 3-6 times, the vaccinated children had asthma and eczema 10-15 times more often than the unvaccinated ones anyway.
Authors, with a clear consciousness, conclude that vaccinations do not increase the risk of asthma or eczema.
Doctors, who only read the abstract (meaning almost everyone, since only few people read these articles in full), only learn of the conclusion and, with a calm heart, go on and continue to vaccinate children.
Such sleights of hand are often found in the studies that allegedly prove the safety of vaccinations.


Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States. 2000, Hurwitz, J Manipulative Physiol Ther

Children vaccinated against tetanus or with the DTP vaccine had asthma twice more often, allergies – 63% more often, and sinusitis – 81% more often, than the unvaccinated ones.


Measles and atopy in Guinea-Bissau. 1996, Shaheen, Lancet

In Guinea-Bissau among children who had measles, allergies were 3 times less common than in vaccinated children who did not have measles. They also had dust mite allergy 5 times less often.
This is explained by the fact that measles virus stimulates cellular immunity, while humoral immunity is responsible for allergies.
Children who were breast-fed for more than a year, and children in whose houses pigs lived, also suffered from allergies less often. Judging by indirect evidence, infections protect against allergies only if the infection occurs at an early age. Most likely, the reaction of T cells to allergens matures until 5-7 years of age, and until that time it changes under the influence of environmental factors, such as infections.
In another study, measles or whooping cough before the age of three years was associated with a reduced risk of asthma.


Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. 2009, Rosenlund, Pediatrics

A study on 14,900 children from five European countries. In those who had measles, allergies were 2 times less common. Vaccination reduced incidence of allergies as well, but not as much as measles.
Amongst those who didn't have measles, the risk of rhinoconjunctivitis was 70% higher in vaccinated than in unvaccinated.
11% of children who were previously vaccinated had measles. On the other side, 31% of unvaccinated children did not get measles. One more similar study.
Antibiotics in the first year of life are associated with 2-fold increase in risk of rhinoconjunctivitis, 2.8-fold increase in risk of asthma, 1.6 fold – of eczema. Antipyretics are associated with an increase in the risk of asthma by 54% and eczema by 32%.


Frequency of allergic diseases following measles. 2006, Kucukosmanoglu, Allergol Immunopathol (Madr)

Those who had measles had lower incidence of allergic diseases. One more: [1].


Atopy in children of families with an anthroposophic lifestyle. 1999, Alm, Lancet

Those who were not vaccinated with MMR had 33% lower incidence of allergies. Those who ate mostly organic foods had 37% lower incidence of allergies.
Allergies were also less common in those who did not use antibiotics, did not use antipyretics, had measles, ate fermented vegetables, or were breast-fed for at least 4 months.


Improvement of food-sensitive atopic dermatitis accompanied by reduced lymphocyte responses to food antigen following natural measles virus infection. 1993, Kondo, Clin Exp Allergy

Five patients with eczema and egg allergy had measles. A month later the symptoms of eczema improved significantly in four of them. The fifth had a temporary improvement.


Infections and atopy: an exploratory study for a meta-analysis of the "hygiene hypothesis". 2004, Randi, Rev Epidemiol Sante Publique

Initial analysis of 10 articles (for a meta-analysis). According to indirect markers, infectious diseases are associated with a 20% reduction of risk of dermatitis, 30% reduction of risk of allergic rhinitis and 40% reduction of risk of asthma.

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