Japan

Vitamin K

Vitamin K prophylaxis to prevent neonatal vitamin K deficient intracranial haemorrhage in Shizuoka prefecture. 1996, Nishiguchi, Br J Obstet Gynaecol

In Japan, the incidence rate of intracranial hemorrhage was 1 in 4,000 babies before using vitamin K. In Germany and the United Kingdom, where vitamin K has been used, the likelihood of hemorrhage was 1 in 30,000. The blood coagulability status in infants was significantly higher when vitamin K2 was given to nursing mothers (15 mg/day from the 14th day after giving birth for two weeks).

Rotavirus

An infant with a gastroenteritis caused by a secondary infection with a Rotarix-derived strain. 2017, Sakon, Eur J Pediatr

Two-months-old girl was vaccinated with Rotarix in Japan, and in 10 days her two-years-old sister was hospitalized with severe gastroenteritis. It turned out that her sister infected her with a mutated vaccine strain of the virus.
A similar case with a RotaTeq vaccine in the USA is reported here. Vaccinated infant infected his brother 10 days post-vaccination with a rotavirus strain that was reassortant of two vaccine strains.

Chickenpox

Incidence of herpes zoster in pediatricians and history of reexposure to varicella-zoster virus in patients with herpes zoster. 1995, Terada, Kansenshogaku Zasshi

15. Pediatricians and family doctors suffer from shingles 50%-87% less often than general population.

Pneumococcal

Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care center before and after the official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. 2014, Oikawa, J Infect Chemother

In Japan, after the start of vaccination against Hib and pneumococcus, colonization with pneumococcal vaccine serotypes decreased, and non-vaccine serotypes increased. In general, colonization with pneumococcus did not change, colonization with the haemophilic rod increased.

Mumps

CDC Pinkbook Mumps

In pre-vaccination times, 15-27% of mumps cases were asymptomatic. The number of asymptomatic cases today is unknown, as it is unclear how the vaccine modifies clinical symptoms. Orchitis (testicular inflammation) is the most common complication of mumps, but it is only possible in post-pubertal males. Orchitis is primarily unilateral. Infertility caused by mumps orchitis is quite rare, even in cases of bilateral orchitis.
Prior to introduction of the vaccine, cases of mumps were not recorded.
Monovalent mumps vaccine is virtually non-existent today, except for Japan, where MMR is still banned, mumps vaccine is not sponsored by the state, and very few people get vaccinated against it.

Measles

Association of measles and mumps with cardiovascular disease: The Japan Collaborative Cohort 2015, Kubota, Atherosclerosis

A prospective study of more than 100,000 people in Japan, who were followed for 20 years.In men who had childhood measles, the risk of dying from cardiovascular disease was 8% lower, and those who also had an illness mumps is 20% lower.
In men who have had mumps, the risk of dying from stroke was 48% lower.
In women who had been ill with measles and mumps, the risk of dying from cardiovascular disease was 17% lower.

SIDS

Report of the Task Force on Pertussis and Pertussis Immunization-1988. 1988, Cherry, Pediatrics

В Японии за 5 лет начиная с 1970-го была выплачена компенсация за 37 случаев смерти вследствие вакцинации, из них 11 случаев СВДС. Затем, вследствие смерти двух младенцев в течение 24 часов после прививки, возраст вакцинации был повышен с 3-х до 24 месяцев, и в последующие 6.5 лет была выплачена компенсация лишь за 3 случая смерти. Авторы заключают, что откладывание вакцинации до 2-х летнего возраста сокращает большинство ассоциированных с ней тяжелых побочных эффектов.

Allergies and autoimmunity

A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. 1999, Nakayama, J Allergy Clin Immunol

The MMR vaccine was added to the Japanese immunization schedule in 1989, and was removed from it in 1993. During this time, not a single case of anaphylactic reaction has been recorded among almost a million of those vaccinated with the gelatin-containing vaccines. And from 1994 till 1997, after Japan went back to monovalent vaccines, anaphylactic reactions have been recorded in 1:84,000 cases after the measles vaccine, in 1:153,000 cases after the rubella vaccine, and in 1:54,000 cases after the mumps vaccine. However, another change happened in the immunization schedule in 1994. Until 1994, MMR was the first vaccine received by children at the age of 18 months, and only after that, they were given the diphtheria-tetanus-pertussis (DTaP) vaccine. Since 1994, the diphtheria-tetanus-pertussis vaccine was given at 6 months old, and only after it, did the children get vaccinated against measles, rubella and mumps. All children who had an anaphylactic reaction to live vaccine have been previously vaccinated with DTaP (and 98% of them received DTaP, which contained gelatin).

Allergies and autoimmunity

Removal of gelatin from live vaccines and DTaP-an ultimate solution for vaccine-related gelatin allergy. 2003, Kuno-Sakai, Biologicals

After the previous study, all Japanese manufacturers removed gelatin from live and inactivated vaccines. The risk of anaphylactic reaction decreased significantly, and became 1-2 per million.
American vaccines contain gelatin. The number of allergens in vaccines is not regulated, and the manufacturers do not check for allergens.
The number of anaphylactic reactions to food in the state of Illinois has increased by almost 3-fold in 5 years.

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