Vitamin K

Vitamin K prophylaxis to prevent neonatal vitamin K deficient intracranial haemorrhage in Shizuoka prefecture. 1996, Nishiguchi, Br J Obstet Gynaecol

In Japan, the incidence rate of intracranial hemorrhage was 1 in 4,000 babies before using vitamin K. In Germany and the United Kingdom, where vitamin K has been used, the likelihood of hemorrhage was 1 in 30,000. The blood coagulability status in infants was significantly higher when vitamin K2 was given to nursing mothers (15 mg/day from the 14th day after giving birth for two weeks).


An infant with a gastroenteritis caused by a secondary infection with a Rotarix-derived strain. 2017, Sakon, Eur J Pediatr

Two-months-old girl was vaccinated with Rotarix in Japan, and in 10 days her two-years-old sister was hospitalized with severe gastroenteritis. It turned out that her sister infected her with a mutated vaccine strain of the virus.
A similar case with a RotaTeq vaccine in the USA is reported here. Vaccinated infant infected his brother 10 days post-vaccination with a rotavirus strain that was reassortant of two vaccine strains.


Incidence of herpes zoster in pediatricians and history of reexposure to varicella-zoster virus in patients with herpes zoster. 1995, Terada, Kansenshogaku Zasshi

15. Pediatricians and family doctors suffer from shingles 50%-87% less often than general population.


Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care center before and after the official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. 2014, Oikawa, J Infect Chemother

In Japan, after the start of vaccination against Hib and pneumococcus, colonization with pneumococcal vaccine serotypes decreased, and non-vaccine serotypes increased. In general, colonization with pneumococcus did not change, colonization with the haemophilic rod increased.


CDC Pinkbook Mumps

In pre-vaccination times, 15-27% of mumps cases were asymptomatic. The number of asymptomatic cases today is unknown, as it is unclear how the vaccine modifies clinical symptoms. Orchitis (testicular inflammation) is the most common complication of mumps, but it is only possible in post-pubertal males. Orchitis is primarily unilateral. Infertility caused by mumps orchitis is quite rare, even in cases of bilateral orchitis.
Prior to introduction of the vaccine, cases of mumps were not recorded.
Monovalent mumps vaccine is virtually non-existent today, except for Japan, where MMR is still banned, mumps vaccine is not sponsored by the state, and very few people get vaccinated against it.


Association of measles and mumps with cardiovascular disease: The Japan Collaborative Cohort 2015, Kubota, Atherosclerosis

A prospective study of more than 100,000 people in Japan, who were followed for 20 years.In men who had childhood measles, the risk of dying from cardiovascular disease was 8% lower, and those who also had an illness mumps is 20% lower.
In men who have had mumps, the risk of dying from stroke was 48% lower.
In women who had been ill with measles and mumps, the risk of dying from cardiovascular disease was 17% lower.


Report of the Task Force on Pertussis and Pertussis Immunization-1988. 1988, Cherry, Pediatrics

В Японии за 5 лет начиная с 1970-го была выплачена компенсация за 37 случаев смерти вследствие вакцинации, из них 11 случаев СВДС. Затем, вследствие смерти двух младенцев в течение 24 часов после прививки, возраст вакцинации был повышен с 3-х до 24 месяцев, и в последующие 6.5 лет была выплачена компенсация лишь за 3 случая смерти. Авторы заключают, что откладывание вакцинации до 2-х летнего возраста сокращает большинство ассоциированных с ней тяжелых побочных эффектов.

Allergies and autoimmunity

A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. 1999, Nakayama, J Allergy Clin Immunol

MMR была добавлена в японский календарь прививок в 1989-м, и изъята из него в 1993-м. За это время не было зарегистрировано ни одного случая анафилактической реакции среди почти миллиона привитых вакциной, содержащей желатин. А с 1994 по 1997 год, после того, как Япония вернулась на моновалентные вакцины, анафилактическая реакция была зарегистрирована в 1:84,000 случаев после коревой вакцины, в 1:153,000 после вакцины от краснухи, и в 1:54,000 после вакцины от свинки. Но в 1994 году произошло и другое изменение календаря прививок. До 1994 года, MMR была первой вакциной, которую дети получали в 18 месяцев, и лишь после этого их вакцинировали от дифтерии-столбняка-коклюша (DTaP). С 1994 года, вакцинация от дифтерии-столбняка-коклюша начиналась в 6 месяцев, и лишь после нее дети получали прививки от кори, краснухи и свинки. Все дети, у которых была анафилактическая реакция на живые вакцины, были до этого привиты DTaP (и 98% из них получили DTaP, которая содержала желатин).

Allergies and autoimmunity

Removal of gelatin from live vaccines and DTaP-an ultimate solution for vaccine-related gelatin allergy. 2003, Kuno-Sakai, Biologicals

После предыдущего исследования все японские производители убрали желатин из живых и из инактивированных вакцин. Риск анафилактической реакции значительно снизился, и стал 1-2 на миллион.
Американские вакцины содержат желатин. Количество аллергенов в вакцинах не регулируется и производители не проверяют наличие аллергенов.
Количество анафилактических реакций вызванных продуктами питания в штате Иллинойс выросло почти в 3 раза за 5 лет.

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