Sudden infant death syndrome (SIDS)

Whooping cough

The True Story of Pertussis Vaccination: A Sordid Legacy? 2002, Geier, J Hist Med Allied Sci.

A long but informative article on the history of the pertussis vaccine. If you still believe that the main goal of pharmaceutical companies is to create effective and safe drugs, this article might make you see things differently; we highly recommend reading it!
- The pertussis toxin is added to the whole-cell vaccine. This toxin increases the permeability of the blood-brain barrier, rendering this barrier more penetrable to other toxins and viruses. In fact, the pertussis toxin itself is a neurotoxin.
- Since the 1930s, it has been known that the whole-cell pertussis vaccine (DTP) is somewhat dangerous and can lead to neurological consequences.
- Since the 1950s, scientists analysed DTP vaccine toxicity in mice, evaluating toxicity based on mice survival and weight. In 1963, it became apparent that there was no correlation between the results in mice and the number of neurological consequences in children.
- In addition to the pertussis toxin (an exotoxin – a toxin that is secreted by a living bacterium), the vaccine component itself contains an endotoxin (a toxin released from a bacterium only after its decay). This endotoxin, whose presence was carefully concealed by the vaccine manufacturers, is in fact, very toxic.
- In an article from 1953, it was stated that practically every vaccinated child suffered systemic intoxication, with often permanent CNS lesions.
- The first acellular vaccine appeared in 1937. While it was widely used in the 1940s, it was later discontinued as the company did not want to invest in clinical trials. In the 1960s and 1970s, other acellular vaccines were widely used, but also got withdrawn from production due to their higher costs.
- After two babies died from vaccination in Japan, the Japanese developed the acellular vaccine that has been used since 1981.
- Sweden banned the whole-cell vaccine in the late 1970s. From 1970 to 1985, no child died of pertussis.
- In Tennessee in 1979, four children died after being vaccinated with the same lot of the pertussis vaccine. At this point, the CDC discovered that the vaccine was associated with sudden infant death syndrome (SIDS). While the director of the vaccine department of the FDA was on vacation, the FDA decided to withdraw the entire lot from circulation. However, when the director returned, he ordered that the whole lot be returned for distribution, apologizing to the pharmaceutical companies and promising them that it would not happen again. After this incident, manufacturers stopped sending entire lots to the same place, and instead, began distributing each lot throughout the country.
- This paper is also about how the pertussis vaccine led to the approval of a law for compensating victims of vaccinations. It also mentions how the Department of Health does everything possible to not compensate the injured, how almost all vaccine experts have a conflict of interest, and how the experts of committees investigating vaccine side effects are selected, and much more. The United States switched to the safer, acellular vaccine in 2001, 60 years after it was developed, and 20 years after Japan started using it. Nonetheless, not only is the whole-cell vaccine still licensed in the US, but pharmaceutical companies still sell the vaccine to the WHO, who then distribute it to other countries whose residents are improperly informed about the potential risks.

Whooping cough

Possible temporal association between diphtheria-tetanus toxoid-pertussis vaccination and sudden infant death syndrome. 1983, Baraff, Pediatr Infect Dis

The DTP vaccine has been associated with sudden infant death syndrome (SIDS) in Los Angeles, and visits to the doctor have also been associated with SIDS.

SIDS

Diphtheria-tetanus-pertussis immunization and sudden infant death syndrome. 1987, Walker, Am J Public Health

The SIDS mortality rate during first 3 days after DTP vaccination was 7.3 times higher than during the 30 days after vaccination. The mortality rate decreased gradually over the four weeks after vaccination. The mortality rate in the first month after DTP vaccination was 2.9 times higher than the mortality rate post this time period.
However, the mortality rate among non-vaccinated with DTP was 6.5 times higher than among vaccinated. This conclusion was made based on six non-vaccinated infants. Mothers of 4 of them were single, 3 were unemployed, 2 received welfare and at least in one of the families physical violence was observed. The authors note that SIDS mortality rate has not changed in the UK after the vaccination refusal became common and the subsequent epidemic of pertussis, and therefore it is unlikely that vaccination against pertussis protects against SIDS.

SIDS

Possible temporal association between diphtheria-tetanus toxoid-pertussis vaccination and sudden infant death syndrome. 1983, Baraff, Pediatr Infect Dis

DTP vaccination and doctor visits are associated with SIDS in Los Angeles. 6 out of 27 infants died within 24 hours of the vaccination, and 17 died in the first week after the vaccination.
This study was criticized because, in the reviewer's opinion, it does not take into account that the period of increased risk of dying from SIDS coincides with the period when infants are vaccinated and then falls sharply. It may therefore have been a coincidence that infants died more often on the first day and the first week after vaccination.

SIDS

Vaccination and unexplained sudden death risk in Taiwanese infants. 2017, Huang, Pharmacoepidemiol Drug Saf

In March 1992, 8 infants in Taiwan died within 36 hours of their DTP vaccination. Seven of them received vaccines from the same lot (which accounted for 58% of the vaccines used at that time), which prompted the authorities to suspend the vaccination of that lot.
The authors analyzed the cases of SIDS in Taiwan between 1996 and 2013 and concluded that the risk of sudden death after DTP is 60% higher in girls within two days of vaccination. The authors conclude that the vaccine probably only accelerated the deaths of these girls for a couple of days, and they were already destined to die from SIDS, just a little later than they actually did.

SIDS

Simultaneous sudden infant death syndrome. 2007, Balci, J Forensic Leg Med

Twins (3.5 months age) received a second dose of DTP and OPV and the first dose of hepatitis B vaccine. They had fever and were given paracetamol. Two days later, both died in their sleep lying on their backs. It was determined that their death was not related to vaccinations, and that they died of an unknown reason.

SIDS

Vaccination and cot deaths in perspective. 1987, Roberts, Arch Dis Child

Twins died simultaneously 3 hours after a DTP vaccination. The authors conclude that this happened after the vaccination by a coincidence, that according to their calculations 9 infants a year are expected to die accidentally within 24 hours after the vaccination in the UK, and that the risk of SIDS in twins is 3 times higher. They point out that the number of reported deaths has not reached the projected number.
In 20 years, only 6 deaths after DTP have been reported, but there have probably been other cases. In the 14 months following this high-profile case, 5 deaths were reported within 24 hours of vaccination.

SIDS

Simultaneous sudden infant death syndrome: case report. 2010, Cevik, Hong Kong J Emerg Me

Two-month-old twins suddenly died 3 days after being vaccinated. It was determined that the deaths were unrelated to the vaccination and they died from SIDS.
The case of simultaneous sudden death of three-month-old twins 5 days after vaccination is described here. They received both 3-month and 1.5-month vaccinations. Cause of death is SIDS.
Here is a case description of simultaneous SIDS in 2.5-month-old twins two weeks after vaccination.
Here is a case of simultaneous SIDS in two-month-old twins, 18 days after the vaccination.
Here is a case of simultaneous death of ten-month-old twins the day after vaccination in 1945. The cause of death was determined to be anaphylactic shock, but nowadays their diagnosis would be considered SIDS. The authors cite several more cases of lethal anaphylactic shock which does not occurs instantly after the injection, but rather a few hours or a day after.

SIDS

Sudden and unexpected deaths after the administration of hexavalent vaccines 2005, von Kries, Eur J Pediatr

The authors researched the mortality rate following administration of two hexavalent vaccines (Infanrix Hexa and Hexavac) in Germany. For children in the second year of life, the mortality rate within 24 hours of Hexavac was 31 times higher than expected.
The authors note that the number of cases of SIDS occurring a few days after vaccination is likely to be underestimated, as these cases are not reported to the Paul Erlich Institute (which documents cases of vaccination adverse events). For example, only one of the six SIDS cases that occurred within two weeks after hexavalent vaccination was reported. This case occurred within 24 hours after the vaccination.

SIDS

Sudden unexpected deaths and vaccinations during the first two years of life in Italy: a case series study. 2011, Traversa, PLoS One

Unlike the previous study, a study of 3 million infants in Italy found no connection between hexavalent vaccine and SIDS in the second year of life. Instead it found that the risk of SIDS during the first week after Hexavac was 2.8 times higher, the risk of SIDS after the first dose of any hexavalent vaccine was 2.2 times higher, and the risk of SIDS during the week after the first dose of any vaccine was 1.5 times higher than in the control group.
The control group consisted of the same infants that were vaccinated, just before they were vaccinated and 14 days after. That is, if an infant died on the 15th day after the vaccination, his death would increase the likelihood that the vaccine was not related to SIDS, since that infant already would be a part of the control group.

SIDS

A modified self-controlled case series method to examine association between multidose vaccinations and death. 2011, Kuhnert, Stat Med

The authors analyzed 300 death cases in Germany using a new statistical method and found that the fourth dose of the penta- or hexavalent vaccine was associated with a 16-fold increase in the risk of SIDS, and any dose of the vaccine was associated with a 2-fold increase in the risk.

SIDS

Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome 2008, Buckley, Clin Exp Allergy

Beta-tryptase is an enzyme that is secreted from mast cells (a type of white blood cell). This enzyme is a marker of anaphylactic shock.
The authors analyzed the plasma of infants who died from SIDS and found that their beta-tryptase levels were significantly higher than those of infants who died with another diagnosis. They conclude that anaphylactic shock may be the cause of SIDS. More: [1] [2]

SIDS

Unexplained cases of sudden infant death shortly after hexavalent vaccination. 2006, Zinka, Vaccine

In six SIDS cases that occurred within 48 hours of being vaccinated with a hexavalent vaccine, autopsies were performed in Munich Institute. 5 of the infants were vaccinated with Hexavac and one with Infanrix Hexa. In addition to neuropathological and histological abnormalities, an unusual swelling of the brain was evident in all cases.
Brain weight gain due to edema or hyperemia (overflow of blood vessels) is mainly observed after DTP vaccination. Two of the three tested for tryptase showed very high levels.
The authors conclude that after the introduction of hexavalent vaccine, the number of SIDS deaths immediately after vaccination increased 13 times.

SIDS

Sudden infant death following hexavalent vaccination: a neuropathologic study. 2014, Matturri, Curr Med Chem

11.8% из 110 случаев внезапной детской смерти произошли в течение недели после вакцинации шестивалентной вакциной (Инфанрикс Гекса и Гексавак).
Авторы предполагают, что некоторые компоненты шестивалентных вакцин могут легко проникать через гемато-энцефалический барьер, который в первые месяцы жизни еще проницаем, и они индуцируют молекулярные изменения ДНК, РНК и белков мозга, регулирующие жизненно важные функции, с последующим летальным расстройством респираторного контроля у предрасположенных младенцев. Они отмечают, что нейротоксичность алюминия, включая его способность пересекать гемато-энцефалический барьер и индуцировать воспалительные и нейродегенеративные изменения, была экспериментально продемонстрирована.

SIDS

Infanrix hexa and sudden death: a review of the periodic safety update reports submitted to the European Medicines Agency. 2018, Puliyel, Indian J Med Ethics

Производитель Инфанрикс Гекса (GSK) периодически представляет конфиденциальный отчет в EMA, где анализируется количество смертей сразу после прививки, и показывается, что это количество ниже, чем ожидаемое от случайного распределения.
Авторы проанализировали три из этих отчетов (15-й, 16-й и 19-й), которые стали публично доступны благодаря итальянскому суду, и обнаружили, что смерти, признанные в 16-м отчете были удалены из 19-го отчета. Если принять во внимание смерти из 16-го отчета, то выходит, что количество смертей в течение 4 дней после вакцинации среди детей старше года значительно превосходит случайно ожидаемое.
Авторы замечают, что поскольку случаи СВДС собираются производителем пассивно, их количество, вероятно, занижено. С другой стороны, ожидаемое количество смертей завышено, так предполагается, что все распределенные дозы вакцины были использованы.
Авторы не понимают, как EMA приняла этот отчет, и призывают производителя объяснить, почему он удалил из отчета эти случаи смерти.

SIDS

Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity? 2011, Miller, Hum Exp Toxicol

До начала современных программ вакцинации "смерть в колыбели" встречалась настолько редко, что она не упоминалась в статистике младенческой смертности. В США национальные кампании вакцинации были начаты в 1960-х годах. Впервые в истории, большинство американских детей должны были получать по несколько доз вакцин, а вскоре после этого, в 1969 году, появился новый медицинский термин - синдром внезапной детской смерти. К 1980-му году СВДС стал основной причиной постнеонатальной смертности.
В 1992 году Американская академия педиатрии, начала кампанию "Back to sleep", которая убеждала родителей укладывать детей спать на спину, а не на живот.
В период с 1992 по 2001 год уровень СВДС снижался в среднем на 8.6% в год. Однако другие причины неожиданной детской смерти (SUID - sudden unexpected infant death) увеличились.
Например, младенческая смертность от удушья в постели увеличилась в среднем на 11.2% в год. Младенческая смертность от удушья по другим причинам, а также смертность от других причин тоже увеличились. В других исследованиях были аналогичные наблюдения.
Анализ данных с 1999 по 2001 год показывает, что уровень СВДС продолжал снижаться, однако значительного изменения в общей постнеонатальной смертности не произошло.
Хотя в некоторых исследованиях не удалось найти корреляцию между СВДС и вакцинами, имеются свидетельства того, что некоторые младенцы более восприимчивым к СВДС после вакцинации. Например, Torch обнаружил, что две трети младенцев, умерших от СВДС, были вакцинированы DTP. Из них 6.5% умерли в течение 12 часов после вакцинации; 13% в течение 24 часов; 26% в течение 3 дней; a 37%, 61% и 70% в течение 1, 2 и 3 недель, соответственно. Torch также обнаружил, что непривитые дети умирали от СВДС чаще всего осенью или зимой, тогда как привитые чаще всего умирали в 2 и 4 месяца - то есть тогда, когда младенцев впервые прививают DTP. Он заключает, что риски вакцинации могут перевесить ее потенциальную выгоду.

SIDS

Вот данные CDC. Уровень СВДС в США с 1992 года значительно снизился, однако если считать все неожиданные смерти вместе, то их уровень снизился на 30% к середине 1990-х, и с тех пор практически не меняется.
Индейцы и афроамериканцы умирают от внезапных причин в 2 раза чаще белых, и в 5 раз чаще азиатов.
Смертность младенцев от удушья в кровати с 1990-х увеличилась более чем в 10 раз, несмотря на то, что рекомендация укладывать детей на спину должна была в первую очередь привести к снижению случаев удушья. CDC, почему-то, никак не комментирует этот факт.
В Австралии то же самое - хотя количество СВДС снижается, количество смертей от удушья увеличивается. Еще: [1]

SIDS

Defining the sudden infant death syndrome 1991, Willinger, Pediatr Pathol

В 1991 году определение СВДС было изменено. Например, вскрытие и расследование места смерти раньше не требовались, а теперь стали обязательными. Также стало необходимо выяснять медицинскую и семейную историю.
Однако, это определение до сих пор используется лишь в 35% случаев, в 7% случаев используется определение 1969 года, а в остальных случаях неясно, что используется. В Миссисипи уровень СВДС в 12 раз выше, чем в Нью Йорке. В некоторых штатах следователи не используют СВДС в качестве причины смерти, если есть подозрению на любую другую причину. Уровень СВДС может различаться в 3-4 раза от округа к округу в одном и том же штате. Еще: [1]

SIDS

Повторное использование матраса ассоциировано с трехкратным риском СВДС. Риск был выше, если матрас был заимствован из другой семьи. Еще: [1]

SIDS

В Швеции уровень СВДС коррелировал с уровнем нитратов в воде.

SIDS

18-месячного ребенка привили MMR, несмотря на то, что он был больной. Он умер через 10 дней. Патологоанатом установил, что смерть ребенка не связана с прививкой, так как его симптомы появились слишком быстро после вакцинации, чтобы быть с ней связанной, и ребенок просто умер от СВДС.

SIDS

В 2011 году здоровый четырехмесячный младенец в США получил 7 вакцин, а на следующий день умер с диагнозом СВДС. В июле 2017-го, суд решил, что вакцины сыграли существенную роль в смерти мальчика, и без их влияния он бы не умер.

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