Guillain–Barré syndrome


Guillain-Barré syndrome among the recipients of Menactra meningococcal conjugate vaccine - United States, June-July 2005. 2005, CDC, MMWR Morb Mortal Wkly Rep

Menactra was licensed in January of 2005, and was recommended for 11-12 year olds, as well as for university freshmen. 5 cases of the Guillain-Barré syndrome were registered with VAERS among vaccinated freshmen between June 10th and July 25th of 2005. In one case, the vaccinated girl already had Guillain-Barré syndrome twice before, at the ages of 2 and 5 years; both times within 2 weeks of vaccination.
CDC concludes that it might be a coincidence, and recommends continuing vaccination. The manufacturer added to the insert that Guillain-Barré syndrome might be related to vaccination.

Hepatitis A

Type A viral hepatitis: epidemiology, diagnosis, and prevention. 1997, Lemon, Clin Chem

70-80 people die each year from hepatitis A in the USA, and those are almost exclusively people over 50 years old. Severe cases of hepatitis A are more likely to occur in people with alcoholic liver disease or chronic hepatitis.
Some of the vaccinated people developed Guillain-Barre syndrome, but it is unclear whether this is due to vaccination.

Haemophilus influenzae

Guillain-Barré; syndrome following immunization with Haemophilus influenzae type b conjugate vaccine. 1993, Gervaix, Eur J Pediatr

Occasionally the vaccination from Hib leads to Guillain-Barre syndrome.


Guillain-Barré syndrome after vaccination in the United States: data from the Centers for Disease Control and Prevention/Food and Drug Administration Vaccine Adverse Event Reporting System (1990-2005). 2009, Souayah, J Clin Neuromuscul Dis

In 1990-2005, VAERS recorded 1000 cases of Guillain-Barre syndrome after vaccination, 63% of them were after vaccination against the flu.


What was the cause of Franklin Delano Roosevelt's paralytic illness? 2003, Goldman, J Med Biogr

In 1921, Franklin Roosevelt, who later became president of the United States, was diagnosed with polio. Roosevelt founded the March of Dimes (NFIP) organization, which funded the creation of polio vaccine and the treatment of the disease, no one doubted his diagnosis The times of any paralysis were polio.
In this article the authors analyze in detail the historical evidence of Roosevelt's symptoms, make a Bayesian analysis of each symptom, and conclude that according to three different methods of analysis, Roosevelt most likely had a syndrome th Guillain-Barre syndrome, not poliomyelitis.


Franklin Delano Roosevelt's (FDR's) (1882-1945) 1921 neurological disease revisited, the most likely diagnosis remains of the Guillain-Barré syndrome. 2016, Goldman, J Med Biogr

The previous article, of course, was sharply criticized, historians and neurologists did not want to lose the poliomyelitis president. In this article, the authors respond in detail to the published criticism, and conclude that in the 13 years that have passed since the publication of their article, No alternative analysis of Roosevelt's disease was published, and that historians and doctors continue to believe in Roosevelt's polio because of confirmation bias and appeal to authority, and also because Guillain-Barre destroys the beautiful history of poliomyelitis, in which Roosevelt's disease is logically linked to his leading role in the victory over poliomyelitis.


Adverse events associated with childhood vaccines other than pertussis and rubella. 1994, Stratton, JAMA

An IOM report, in which, among other things, is stated that they have found a causal relationship between tetanus/diphtheria vaccine and Guillain-Barré syndrome, anaphylactic shock and brachial neuritis.

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